New York, USA – As a pioneer engaged in antibody field for over 10 years, Creative Biolabs has established a comprehensive one-stop antibody-drug conjugate (ADC) development platform, which enables a highly efficient customization and production for ADC toxins, ADC linkers, Drug-linker complex and custom ADC.
Deemed one of the most promising treatments that integrate the traditional chemotherapy and the conventional immunotherapy, antibody-drug conjugates consist of a monoclonal antibody, a toxic payload and a linker, characterized by high specificity and affinity towards well-defined targets, and an expanding therapeutic window.
Aiming to support global researchers with ADC projects, Creative Biolabs not only specializes in one-stop ADC services that cover the entire process for a successful ADC, ranging from antibody identification to ADC evaluation, but also provides a wide variety of ADC products in stock with fast delivery services.
ADC toxins play a significant role in targeting intracellular pathways with higher efficiency. At Creative Biolabs, a full list of potent ADC toxins of over 95% high purity is prepared, including but not limited to common auristatins, maytansinoids, calicheamicins, or innovative toxins such as amatoxin.
Products: Auristatin E, Auristatin F, Dolastatin 10, Maytansinol, MMAD, MMAF
ADC linkers are fundamental components that connect antibody and payloads and control the release mechanism of an ADC. For the sake of an easy-to-operate conjugation process and an excellent chemical and serum stability of ADC, Creative Biolabs provides a comprehensive list of ADC linkers.
Products: cleavable linkers (pH-sensitive linkers, disulfide linkers, peptide linkers, ß-glucuronide linkers), non-cleavable linkers, and intermediate linker modules.
In addition, Creative Biolabs also offers numerous pre-assembled drug-linker complexes of high quality using LC-MS and 1HNMR spectroscopy for ready-to-go antibody conjugation to accelerate ADC development processes in the most effective manner. It’s worth mentioning that these drug-linker complexes are available from milligram for research and development to gram for large scale preparation or even GMP ADC manufacturing.
Products: Cys-mcMMAD, DBCO-PEG4-MMAF, DBCO-PEG4-Ahx-DM1, Mc-MMAD, Mc-MMAE, SMCC-DM1
“Through years of efforts in the ADC development for years, we are capable of serving our customers the best service and products with a fast turnaround time. Our seasoned experts are ready to help clients with customized projects,” introduced by the manager at Creative Biolabs.
More information can be reached at https://www.creative-biolabs.com/adc.
About Creative Biolabs
With more than a decade of exploration and expansion, Creative Biolabs provides current research and service capacity that covers the entire new drug discovery and development pipeline, ranging from early discovery, pre-clinical evaluations, cGMP manufacturing, to clinical trials. As an international cooperation, Creative Biolabs established offices all around the globe with more than 200 well-trained full-time scientists and technicians, who work closely with customers and research partners to develop new medicines for a better, healthier world. After years of pursuit for perfection, Creative Biolabs has established leadership in targeted immunotherapy and antibody-drug conjugate (ADC) development. They offer customers comprehensive one-stop-shop of all aspects in ADC research and evaluation, ranging from antigen selection, antibody production/optimization, payload-linker synthesis, ADC conjugation, to various stages of ADC characterization and pre-clinical evaluation.