Noninvasive Glycometabolism Monitoring Technology Barrier was Successfully Cracked in China

Recently, it is said that the noninvasive glycometabolism monitoring technology barrier has been successfully cracked in China and one kind of new measuring method that will cause no damage to the body surface has been developed which will conduct real-time monitoring of the current rate of glucose metabolism of the human body.

This kind of technological mean has been gradually for the noninvasive monitoring of the blood glucose of diabetic patients through the monitoring of the rate of glucose metabolism of the human body which has been regarded as an important breakthrough in the field of blood glucose monitoring.

According to the introduction of relevant technical staff, the foundation of noninvasive glycometabolism monitoring technology is the measurement of rate of glucose metabolism which is the energy value (H) produced by the glucose metabolism in the human body within the unit interval and the superficial area of unit skin. The rate of glucose metabolism is the function of metabolic heat of the human body (Q), the blood flow rate (BF) and the oxyhemoglobin saturation (O), i.e. H=f(Q,BF,O).

Data of the rate of glucose metabolism can be obtained through the measurement of parameters using the sensor combined with arithmetic design. The rate of glucose metabolism has been proved to be related to the height of glucose molecule concentration in the blood through medical experiment, which means the rate of glucose metabolism can not only reflect whether the metabolic process of the body is normal or not but also reflect the current blood glucose concentration value of the body.

—G— The rate of glucose metabolism

—R— The concentration of blood glucose

It is well-known that the invasive glucometer or the venous blood is generally used to evaluate the health condition of glucose metabolism of the human body in the current medical detections. The proposition of noninvasive glycometabolism monitoring technology in China has avoided the psychological disorder or possible secondary damage to the testees through invasive blooding which will be replaced by the noninvasive measurement for the rate of glucose metabolism. This has not only made great progress in glycometabolism monitoring technology but also provides a new perspective for noninvasive blood glucose detection.

The reporter is informed that there are two kinds of common blood glucose monitoring technologies in the global market which is electrochemistry method and light reflection method through interviewing medical experts.

The electrochemistry method adopts the principle of testing the current signal produced during the blood and current reaction to reflect the blood glucose level, reads the quantity of the electron that are produced through the reaction of enzyme and glucose which passes through the current counting facility and then turns it into the reading of the glucose concentration.

The light reflection method reflects the blood glucose level through the color change of test strips during the blood testing and test paper reaction process. It tests the intensity of reflected light on the reflecting surface of the testing paper using the detector and then turns the intensity of reflected light into the glucose concentration through the intermediate (colored substance) produced during the reaction of enzyme and glucose.

Undoubtedly, invasive blood collection is required by these two detection methods. Since such data collection manner has all sorts of disadvantages and inconveniences to the subjects, scientists started ongoing study on the noninvasive monitoring of blood glucose as early as half a century ago. One common way is to measure the glucose concentration of blood substitutes (saliva, sweat and urine), but some studies have shown that the concentration of glucose detected and the concentration of blood glucose has no significant correlation. Another way is to measure the concentration of glucose in interstitial fluid by mild corroding the skin, removing the skin barrier and vacuum continuous extraction, and then through the reverse algorithm to presume the concentration of blood glucose. But this is still a slight detrimental detection method by using the osmotic technology in combination with in vitro measurements, the correlation of glucose concentration and concentration of blood glucose is indeed quite good, but high operation technique is required during the detection process, and the measuring is too complex for common clinical use.

From the perspective of data connection method, noninvasive glycometabolism monitoring technology can realize the collection of calorific value of human metabolism, blood flow and blood oxygen concentration through body surface detection. From the perspective of correlation, the rate of glucose metabolism primarily reflects the unit area and the energy value per unit time after the in vivo glucose metabolism, which has a direct relationship with the blood glucose. Noninvasive monitoring of glycometabolism rate demonstrates the feasibility of noninvasive blood glucose monitoring technology on the positive sight, and can effectively prevent monitoring accidents such as cross-infection which may occur during invasive blood glucose monitoring.

Starting from the medical monitoring area, diabetic relies on the blood glucose monitoring technology most. Patients who are diagnosed with diabetes and treated with insulin or using insulin pump need to monitor the blood glucose level 4-7 times per day. The psychological consequences of invasive blood glucose detection to the patient are unpredictable. Most patients said that they will try to avoid the detection of blood glucose concentration when they feel good, which is one important reason of having difficulty in real-time monitoring and control of diabetic state. As reported by the World Health Organization, there are 150 million people died of diabetes each year. Under the plight of the world’s medical monitoring technology, the advances of Chinese “noninvasive” technology of monitoring glucose metabolism will fundamentally solve patient’s fear of glucose monitoring, and inevitably lead the control and treatment of diabetes into a new era.

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