Creative Biolabs developed custom anti-idiotypic antibody (anti-ID Abs) production and downstream assay services to support clients’ study, preclinical and clinical trials and the development of monoclonal antibody drugs.
Creative Biolabs is experienced in developing high specificity and high affinity antibody from various species, including rabbit, chicken, llama, camel, alpaca, cow, dog, mouse, rat, sheep and human. In addition to mouse and rat hybridoma production methods, Creative Biolabs also utilizes phage display immune antibody library construction and screening methods which are regarded as the best method to raise monoclonal antibodies from species that do not have hybridoma technology available. It provides both custom anti-idiotype antibody production services and products to meet specific needs from researchers.
“Three approaches are used in developing anti-idiotypic antibodies, Immunized phage display library technology, premade non-immunized human phage display library technology and Hybridomas technology”, introduced Dr. Monika, scientific officer of Creative Biolabs.
Immunized Phage Display Library Technology
Target antibody in the forms of whole IgG, scFv, Fab or F(ab’)2 or peptides designed according to the sequences of the variable domains is utilized to immunize animals. Isolated immunized antibody library is packaged to phage library and anti-ID antibodies can then be generated by biopanning for 3-4 cycles.
Premade Non-immunized Human Phage Display Library Technology
Technology in the absence of immunization suits perfectly for the conformational epitope targeting anti-idiotypic antibodies, since in vitro selection well maintains the correctly folded conformation of target antibody.
scFv/Fab forms of target antibodies are utilized to immunize rats or mice in the presence of isotype matching control antibodies for counter-selection.
About Creative Biolabs
Creative Biolabs is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early antibody drug discovery and development.
Company Name: Creative Biolabs
Contact Person: Candy Swift
Address:45-1 Ramsey Road
State: New York
Country: United States