In order to further support researchers in the field of Fab antibody research, Creative Biolabs updated its list of Fab antibodies. It is now able to provide the most comprehensive list of this antibody type.
The Fab fragment is an antibody structure that still binds to antigens but is monovalent with no Fc portion. Fab fragment antibody is a special antibody consisting of four domains, VH, CH1, VL and CL1. The Fab fragment has 440-450 amino acids and its molecular weight is about 47-48 kDa. Compared with the full length antibodies, Fab fragment has its own features.
On the one hand, it is easy to penetrate tissues and can be generated by some simpler expression systems, such as E. coli. On the other hand, the Fab fragments lack Fc regions so that the interactions between Fc portions and Fc receptor will be removed. Therefore, the Fab fragments can enhance antibody specificity and reduce the effector functions. Fab fragment antibodies will become increasingly important and popular.
Currently, there are three Fab fragment antibodies on the market, abciximab (ReoPro®), ranibizumab (Lucentis®) and certolizumab pegol (Cimzia®).
“Our scientist are also working hard to produce more and better Fab fragment antibodies to meet customers’ demands”, said Dr. Monika, scientific officer of Creative Biolabs.
About Creative Biolabs
Creative Biolabs is a biotech service provider of therapeutic antibody discovery and manufacturing, offering high quality service to customers in academia and industry fields all over the world. Its products range from antibody/peptide libraries, biosimilar cell lines, chimeric antigen receptor (CAR) products, conjugate antibodies to engineered antibodies such as therapeutic antibodies, single domain antibodies, bispecific antibodies and intrabodies.
Company Name: Creative Biolabs
Contact Person: Bella Smith
Address:45-1 Ramsey Road
State: New York
Country: United States