Fluorescence lifetime imaging microscopy (FLIM) is a technique utilized to measure the fluorescence lifetime of molecules. The fluorescence lifetime is the average time a molecule spends in an excited state before returning to the ground state. This measurement is a highly quantitative value that can be used to determine molecular dynamics with nanoscale resolution. FLIM is a standard technique for determining the lifetimes of fluorescent molecules in cells, tissues and whole animal models.
Fluorescence lifetime imaging microscopy (FLIM) produces an image based on the differences in the excited state decay rate from a fluorescent sample. Thus, FLIM is a fluorescence imaging technique where the contrast is based on the lifetime of individual fluorophores rather than their emission spectra. The fluorescence lifetime is defined as the average time that a molecule remains in an excited state prior to returning to the ground state by emitting a photon.
Multi-color staining with fluorescent dyes is actively used for observing the distribution of biological materials (such as proteins, lipids, nucleic acids, and ions) in the field of tissue and cell research. The detection technology for fluorescence observation has advanced to a level at which a single fluorescent dye molecule can be detected under the best of circumstances. Factors such as rising global focus on nanotechnology, favorable government and corporate funding and technological advancements such as super resolution microscopy; high-throughput techniques and digitization of microscopes are driving the microscopy market.
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However, the high cost of advanced microscopes; implementation of excise tax by the U.S. government; and the heavy custom duty on medical devices are hindering the growth of this market. On the other hand, novel application areas such as optogenetics and high potential emerging markets such as China, Japan, and Middle East represents significant growth opportunities for the key players in the microscopy market.
Further, time consuming sample preparation process for advanced microscopes and requirement of high degree of technical expertise to handle complex microscopes may pose challenges to the growth of this market during the forecast period. The global fluorescence lifetime imaging microscopy market is segmented on the basis of application and geography. On the basis of application, the global fluorescence lifetime imaging microscopy market is segmented into semiconductor, chemical industry, medical care, academic institutes and so on.
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On the basis of application, the global fluorescence lifetime imaging microscopy market is segmented into North America, Asia Pacific, Europe, Latin America and Middle East & Africa. North America is expected to account for the largest share of the microscopy market, followed by Europe. Both markets are estimated to register single-digit growth rates during the forecast period.
However, Asia Pacific is expected to register a higher growth rate during the forecast period, owing to huge investment opportunities in this region. The growth of the global fluorescence lifetime imaging microscopy market in the Asia Pacific region will revolve around China, India, Australia and countries in the Middle East. The key players of global fluorescence lifetime imaging microscopy are Leica microsystems, Brucker, Fly limited, Olympus Corporation, Asylum, Japanese Electronics Co. Ltd., Micro engineering in Denmark, Hitachi High-Technologies Corporation, Carl Zeiss AG and Nikon Corporation.
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