Creative Biolabs, with years of experience in the field of antibody development and research, has successfully established and applied its special DNA immunization service system for hundreds of antibody discovery projects.
As an advanced strategy, DNA immunization enables the immunized hosts to produce interested antigens in vivo with common post-transcriptional modifications and then induce a powerful immune response.
Compared to traditional immunization methods, DNA immunization permits in vivo antigen production, omitting the time-consuming processes of immunogens synthesis and purification, such as peptides and recombinant proteins. In addition, these in vivo expressed proteins can maximally maintain the naïve structures and go through appropriate post-transcriptional modifications. These properties can contribute to the generation of high-affinity antibodies against the natural conformation of the target antigen, which is a crucial feature for developing therapeutic antibodies. What’s more, this approach is an ideal solution to develop antibodies against membrane proteins or other challenging or problematic antigens, and is also a novel tool in the early phases of DNA vaccine development.
Creative Biolabs developed a series of DNA immunization strategies for specific project objectives, including MagicTM DNA Immunization Strategy, Gene Gun DNA Immunization Strategy, In Vivo Electroporation DNA Immunization Strategy, Naked DNA Immunization Strategy and Heterologous Immunization Strategy.
It has also developed MagicTM DNA immunization service system to transfect the immune plasmid into cell line for the immune response validation and further screening. “Based on this system, we can provide a series of specific MagicTM transfection reagents as individual products for our clients”, said Dr. Monika Müller, chief scientific officer of Creative Biolabs, “Magic TM reagents can achieve high efficiency in vitro transfection of either DNA, mRNA or siRNA for a broad range of cell types of cell lines to assist scientists’ research and project development.”
About Creative Biolabs
Creative Biolabs is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early drug discovery and drug development. As a trusted provider of the most cost-effective outsourcing solutions, Creative Biolabs has been working for a large number of satisfied clients from biotechnology and pharmaceutical companies as well as government and academic research laboratories all over the world.
Company Name: Creative Biolabs
Contact Person: Bella Smith
Address:45-1 Ramsey Road
State: New York
Country: United States