With over ten years of experience in antibody-drug conjugates, Creative Biolabs recently released a comprehensive antibody design and conjugation service to fit various bio-conjugation strategies for global clients.
Antibody-drug conjugate (ADC) is comprised of an antibody, a payload, and a linker. As the key for target specificity, the antibody serves as the cargo to deliver the payload. Conjugate meaning in ADC development refers to attaching a payload drug to different sites on the antibody.
“In order to achieve more precisely controlled site-directed conjugations and subsequently a narrower distribution of conjugate dar, special moieties with unique conjugation chemistries are engineered into antibody sequences in our antibody design services,” said Dr. Monika Müller, Scientific Officer of Creative Biolabs.
“We also incorporate Cysteine residues into defined sites on an antibody to create thiol-engineered antibody (EnCys-mAb) and conjugate payload drugs onto those Cysteine residues via thiol-based chemistry. And an enzyme-mediated modification and conjugation system is developed to help generate ADCs with specific conjugation sites in dar conjugation.”
A chemically compatible antibody plays a significant role in the conjugation chemistry, which means antibody design directly dictates the fate of an ADC project. With expertise and dedication, advanced antibody design platform and services from Creative Biolabs will be the best companion in creating customized ADCs.
About Creative Biolabs
Established in 2004, Creative Biolabs is highly specialized in advanced antibody biochemistry and engineering. With more than a decade of exploration and expansion, our current research and service capacity covers the entire new drug discovery and development pipeline, ranging from early discovery, preclinical evaluations, cGMP manufacturing, to clinical trials. As an international cooperation, we have established offices all around the globe with more than 200 well-trained full-time scientists and technicians, who work closely with our customers and research partners to develop new medicines for a better, healthier world.
Company Name: Creative Biolabs
Contact Person: Bella Smith
Address:45-1 Ramsey Road
State: New York
Country: United States