New York – Apr 2nd, 2018 – Creative Proteomics is proud to introduce the peptide purity analysis and Structure-Activity Relationship (SAR) Analysis for understanding peptide characterization. In which, peptide purity analysis help figure out the various functions of different peptides with professional HPLC platform while SAR analysis will be effective to detect the active structure of polypeptide organisms.
The purity of peptides is a key factor that influences the success and meaningful results of a research project. That’s why peptide purity analysis, contaminant detection and residue content are widely performed in various industries. Common contaminants of peptide products come from chemical synthesis, culture media or from extraction and purification steps. And impurities consist of missing sequences, incompletely deprotected sequences, truncated sequences, and byproduct synthesis. Creative Proteomics has developed a highly sensitive reversed-phase HPLC platform to analyze peptide purity. The purity of peptides analyzed by Creative Proteomics can be applied in the various field, and the recommended purity based on peptide application will be as follow:
95% to 99% – recommended for quantitative analysis and structural studies, such as SAR analysis
85% to 94% – Suitable for most qualitative and semi-quantitative biochemical analysis.
70% to 84% – Suitable for many screening and research applications
Development and Potential Issue for SAR Analysis
SAR analysis now has a greater effect on dealing with large and growing sources of data as it allows the detection of functional groups that have a biological effect on the organism, which allows modification of biologically active compounds by changing their chemical structure. Chemists introduce new chemical groups into biomedical compounds and test the effects of modification on their biological functions via utilizing advanced chemical synthesis techniques.
The basic assumption of SAR analysis is that similar molecules have similar functions. Therefore, the potential problem is how to define small differences at the molecular level as each activity such as reactivity, solubility, target activity, etc., may be different from the other. At present, Creative Proteomics offers several professional SAR analysis to analyze chemical structure and activity, involving Multiple Linear Regression (MLR), Principal Component Analysis, Artificial Neural Networks (ANN), Support Vector Machine (SVM).
About Creative Proteomics
Creative Proteomics, as the proteomics division of Creative Dynamics Inc., specializing in a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies. The mainstream services include protein separation, characterization, identification, and quantification services, featured with high throughput and super-sensitivity. Creative Proteomics offer professional service systems for life sciences, analytical laboratories in the whole world. The Company’s products are used in many industries such as pharmaceutical, biotech, chemical, as well as academic research.
Company Name: Creative Proteomics
Contact Person: Melissa George
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States