New York, US – December 19th, 2018 Creative Biolabs, a trusted partner engaged in antibody field, recently published BsAb engineering services to customize bispecific IgGs and appended IgGs to meet the specific requirements of clients in the scientific and industrial field.
Bispecific antibodies (BsAb) are artificial antibodies that bind two different antigens, or two different epitopes on the same antigen. BsAb engineering service opens up many new potential therapeutic applications from the fields of immunotherapy, chemotherapy, radiotherapy, and gene therapy, in which the properties of BsAbs can be customized such as valency, size, half-life, flexibility, etc.
As a widely used BsAb format that is monovalent for each antigen, bispecific IgGs remain the general size and structure of a conventional IgG and thus have the most similar biophysical properties to a regular IgG including serum high stability, half-life and tissue penetration. Based on years of experience in BsAbs manufacturing, scientists in Creative Biolabs usually use mammalian cell lines as hosts to produce bispecific IgGs by recombinant expression or hybrid-hybridoma technology.
Appended IgGs refer to IgGs based molecules with additional antigen-binding moieties. The antigen-binding moieties may be Fab, scFv, Fv, single domain antibodies or engineered protein scaffolds. Appended IgGs are generated by genetic engineering which enables the molecule design to be adapted to the desired activity. The distance of two antigen-binding domains can be customized which is realized by the additional binding units at the distal end of the heavy chain. There are more artificial linkers used in appended IgGs than that in conventional IgGs and IgGs.
In addition, customized BsAb engineering services offered by Creative Biolabs also cover bispecific antibody fragments, bispecific fusion proteins, bispecific antibody conjugates. Scientists from CBL can engineer BsAbs of different subtypes from various species to meet the unique requirements of every client. For more detailed information, please visit https://www.creative-biolabs.com/bsab.
About Creative Biolabs
Creative Biolabs was established in 2004 by scientists who are dedicated to conquering of cancer. Over the past 10 years, Creative Biolabs has grown into a recognized world leader in antibody (rAb) discovery, engineering, production, and analysis. Standing on the shoulder of a giant, their bispecific antibody (BsAb) team has a collective of experienced scientists committed to providing high-quality service to customers all over the world. Creative Biolabs has been dedicated to the development of techniques. Now, with the cutting-edge platforms and methods (quadroma development, chemical conjugation, and genetic engineering), a comprehensive list of bispecific antibody products is available to customers in academia and industry fields.
Company Name: Creative Biolabs
Contact Person: Bella Smith
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States