New York, US – Dec 28, 2018 – Creative Biolabs, a leader in the field of recombinant antibody discovery and manufacturing, is able to provide superior neutralizing antibodies to help prevent viral infections. With years of experience in the field, the company has offered a broad range of specific neutralizing antibody products to meet the diverse market demands.
Antibodies are responsible for protecting health, while the way they work differs a lot. Generally, antibodies can be classified into the neutralizing antibody (NAb) and the non-neutralizing antibody (Ab). A typical antibody is produced after the immune system suffers viral infections. Such antibodies bind to an antigen and flag it, while sending a signal to the white blood cell that this antigen has been targeted. Afterward, the antigen is processed and destroyed. On the other hand, such antibodies have the potential for worsening infectivity. Since they can both bind to virus particles and interact with receptors on macrophages, the whole virus-antibody complex enters the cell by virtue of endocytosis. Then the viral proliferation begins. Such antibodies fail to neutralize infectivity; on the contrary, they enhance it. They are known as non-neutralizing antibodies. A neutralizing Ab prevents an infectious agent or virion from infecting a cell by neutralizing or inhibiting its biological effect.
“When it comes to the antibody class, I’d like to quote someone. He said ‘antibodies can simply bind to IFN-beta or glatiramer acetate with no subsequent effect on function, or they can block or neutralize their biological activity.’ The former refers to the non-neutralizing antibody or the binding antibody, and the latter to the neutralizing antibody. The two antibodies work in different ways. A binding antibody simply flags the antigen which ends up being destroyed by white blood cells, while a neutralizing antibody emerges as an immune response to inhibit the effect of foreign receptors, excluding the need for white blood cells. An antibody neutralizes viral infectivity in plenty of ways. It hinders a virion from binding to receptors, blocks uptake into cells, prevents uncoating of the genomes in endosomes, or causes aggregation of virus particles. Finally, most of the enveloped viruses end up being lysed, thereby protecting the immune system,” a scientist from Creative Biolabs said.
A typical example of a neutralizing Ab is diphtheria antitoxin, which neutralizes the biological effect of diphtheria toxin. At present, the application of the NAb has extended to the treatment of influenza and HIV, hepatitis C, dengue and West Nile virus, etc. In addition, associated evidence has shown that in the future the NAb may possibly serve as a vaccine conferring long-lasting immunity.
About Creative Biolabs
Creative Biolabs was founded by scientists who are dedicated to the treatment of diseases including immune disorders, cancers and infections. Thanks to its cutting-edge hybridoma development and phage display platforms, the company is able to produce the most comprehensive list of recombinant antibody products and extensive service portfolio at the most competitive price.
Company Name: Creative Biolabs
Contact Person: Bella Smith
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Address:45-1 Ramsey Road
State: New York
Country: United States