New York – February 27, 2019 – As a leading custom service provider in antibody field, Creative Biolabs now offers a range of epitope-specific antibody design services with high specificity and affinity.
Although antibodies have become potent tools in numerous science fields due to the ability to bind certain molecules with high affinity and specificity, it may be difficult to produce antibodies to target specific epitopes within a protein, especially when these epitopes are not effective antigens. Therefore, Creative Biolabs has established a more rational strategy to epitope-specific antibody design, which is peer-reviewed protein engineering algorithm based on natural mAb backbone conformations and sequences.
Taking advantage of our exclusive design strategy, scientists in Creative Biolabs can offer two high-quality antibody structure modeling services to contribute greatly to antibody development. First, the homology modeling uses the 3-D structures of protein molecules with similar sequences as “templates” and generate a structure depended on the template structures combined with the AA differences between the template and the modeled sequence. Second, antibody de novo modeling, which mainly includes loop grafting and de novo modeling, are provided for a higher success rate. Essentially, loop grafting directly copies the crystal structure coordinates of a known loop of similar length and performs quite well for CDR L1, L2, L3, H1 and H2 loops. De novo modeling does not depend on existing structural templates for the loop regions and can be utilized to predict, without bias, the conformation of these crucial antibody features.
“Since antibodies serve as an increasingly important role in both research fields and science industry, the study of antibody-antigen complex is required to reveal the common principles of recognition, as well as the basis for the successful design of novel molecules or the rational optimization of existing ones. Therefore, we have established an advanced antibody-antigen complex modeling process based on the computational docking to better study antibody-antigen complex, which discovers the relative transformation and conformation of the antibody and antigen involved in energetically favorable complex formation. Importantly, our modeling service takes into consideration of the latest scientific knowledge of antibody-antigen interactions and conformational flexibility of the CDR region (especially the H3 loop),” said a scientist in Creative Biolabs.
With the high-quality epitope-specific antibody design service, the experienced scientists here at Creative Biolabs are dedicated to helping global clients develop epitope-specific antibodies. In addition, various services regarding in silico technology are also available. Please visit https://www.creative-biolabs.com/preciab/ for more detailed information.
About Creative Biolabs
Creative Biolabs was founded by scientists who are dedicated to the conquering of cancer, believing that a custom-service-centered business model is important for optimizing the drug development process, leveraging accessible resources, and forming a team of various background to conduct drug discovery in future. The service portfolio includes mouse and rat monoclonal antibody production using hybridoma technology, human, monkey, rabbit, chicken, dog, llama and camel monoclonal antibody production using various antibody library technologies (including phage display, bacterial display and yeast display). In addition, OEM services for bulk scale antibody manufacturing, including bacterial production of scFv, diabody, tandem scFv, miniantibody and Fab, and mammalian cell expression of minibody, chimeric IgG and IgG, are also available at the most competitive price in the industry.
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States