New York, May 27, 2019 Creative Biolabs, a valuable partner who focuses on bispecific antibody (BsAb) development for years, now offers three featured BsAb development services targeting at different needs from global clients.
1 Bispecific antibody mimetics development
Equipped with higher stability, reduced size, efficient recombinant features, few or no cysteines, etc, alternative scaffolds, a class of BsAb mimetics, are well suited for the production of bispecific proteins. In Creative Biolabs, technicians can design BsAb mimetics and improve their biological functions by blocking two receptors in the same signaling pathway, using one moiety of bispecific scaffold proteins to attract an effector function, etc. They are also able to provide one-stop solutions to offer bispecific antibody mimetics including Avimers, Bispecific Single-Domain ABD Molecules, Albumin-Binding Domain. Meanwhile, a stable framework can be manufactured with one or more randomized loops (the IgG fold belongs to this class) and scaffolds.
2 Bispecific Antibody-drug Conjugates Development
The selectivity, internalization, payload delivery, and acquired resistance of Antibody-drug conjugates (ADC) can be greatly benefited from bispecific approaches. Creative Biolabs provides many different BsAb formats including but not limited to Tandem scFv, Tandem Fab, Diabody, IgG-scFv, CrossMab, etc., for BsAb-drug conjugates development. Experts will assist clients in selecting the suitable binding modality to match the proposed mechanisms of action and the specific clinical applications, seek the bispecific technology to increase the ability of ADC targeting and promote endocytosis and lysosomal trafficking based on fast-internalizing receptor, crosslinking and clustering of receptors.
3 Cell-free BsAb Expression
Cell-free protein synthesis, also termed in vitro translation, facilitates the production of a target protein by translational machinery without relying on living cells. Scientists in Creative Biolabs make use of advanced cell-free expression systems for the synthesis of various BsAbs and many other antibody fragments of varying origins, classes and properties. For Prokaryotic Cell-Free Systems, Creative Biolabs can provide E. coli-based cell-free translation system for required BsAb products and perform laborious purification steps to refrain BsAbs from contaminated with endotoxins in E. coli. For Eukaryotic Cell-Free Systems, Creative Biolabs offers a more suitable environment for the folding of complex antibody molecules, that includes but not limited to rabbit reticulocyte lysate (RRL), wheat germ lysate, insect cell lysate, and human cell lysate. Notably, this system provides post-translational modifications (e.g. core glycosylation or phosphorylation), and natural membrane elements (e.g.microsomes) for membrane protein insertion.
As a leading custom service provider industry leader in the field of antibody engineering, Creative Biolabs has gained a great reputation worldwide by virtue of rigorous academic teams, advanced technique platforms, and considerate services. More information on BsAb services and products can be reached at https://www.creative-biolabs.com/bsab.
Creative Biolabs was established in 2004 by scientists who are dedicated to conquering of cancer. Over the past 10 years, Creative Biolabs has grown into a recognized world leader in antibody (rAb) discovery, engineering, production, and analysis. Standing on the shoulder of a giant, the bispecific antibody (BsAb) team has a collective of experienced scientists committed to providing high-quality services to customers all over the world. Now, with the cutting-edge platforms and methods (quadroma development, chemical conjugation, and genetic engineering), a comprehensive list of bispecific antibody products is available to customers in academia and industry fields.
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States