On June 25, Creative Peptides, one of the world’s leading peptide vendors, announces to release protein glycosylation service for scientists who are engaged with relevant biological research. Previously Creative Peptides already provides other peptide modification services like custom conjugation, peptide N-Terminal modification, peptide C-Terminal modification, post-translational modification and more.
Among over 20 post-translational modification processes in eukaryotic animal cells, glycosylation is one of the most common protein modifications, compared with others like ubiquitination, lipidation, phosphorylation, methylation and acetylation. As estimated, over half of mammalian proteins are glycosyalted. In a wide range of biological processes such as transporting molecules, production of enzymes or acting as cell attachment-recognition sites, glycoproteins all play a vital role.
“The varying types and structures of glycoproteins allow them to adapt to all those different functions. Glycans have a variety of critical structural and functional roles in membrane and secreted proteins. About half of all proteins undergo glycosylation to avoid incorrect folding of the original proteins,” explains Dr. Robert Martinez, Head of Creative Peptides’ synthesis and modification business, in a release conference. “There are two common types of protein glycosylation, that is, O-linked and N-linked. It is very important to characterize and locate these sites if we want to understand how the envelope mutates, and if lucky enough, we can perhaps find sites that could be used for targets for broadly neutralizing antibodies.”
Synthetic glycopeptides have presented a unique frontier for the investigation and better understanding in both glycobiology and proteomics, and may also contribute to the development of biotechnological or therapeutic applications. “Glycosylation is regarded as one of the most important determining factor for product quality, which could influence the biological activity, serum half-life and immunogenicity of the protein. In some cases, glycosylation could improve the molecular stability and solubility of protein,” adds Dr. Robert Martinez.
Recognizing that different clients and researchers have specific and unique requirements regarding to their demands, Creative Peptides provides the commonly seen monosaccharide, disaccharide and polysaccharide services. But apart from that, other glycosylation modifications (sialic acid, fucose, etc.) can also be performed on the main chain and side chain of the polypeptide.
For more information about protein glycosylation at Creative Peptides, please visit: https://www.creative-peptides.com/services/protein-glycosylation.html.
About Creative Peptides
As a US-based expert aimed at creating a better and healthier world for the human beings together with concerted efforts from many industries, Creative Peptides keeps enriching its peptide related product and services in the last two decades, with a comprehensive product range covering cosmetic peptides, catalog peptides, checkpoint inhibitors, therapeutic peptides as well as a one-stop peptide synthesis, modification and analysis service, including Stapled Peptide Synthesis, Long Peptides Synthesis, Cyclic Peptide synthesis, Oligopeptide Synthesis, Post-translational Modification, Peptide Drug Discovery, Peptide Lead Optimization, etc.
Company Name: Creative Peptides
Contact Person: Cathy Miller
Email: Send Email
Address:45-16 Ramsey Road
Country: United States