New York, US, August 29 As a specialized custom service provider for therapeutic glycoprotein development, Creative Biolabs announces a portfolio of glycoprotein production and corresponding analysis services, including but not limited to Custom Glycoprotein Synthesis and Glycoprotein Detections services.
Therapeutic glycoprotein containing oligosaccharide chains (glycans) covalently attached to amino acid side-chains plays a significant role in modulating yield, bioactivity, solubility, stability against proteolysis, immunogenicity, and clearance rate from circulation.
With the intention of optimize the glycoproteins synthesis process, which was hindered by the limitations from homogeneous glycans obtaining, production of the protein backbone， and linkage between glycan and protein backbone, scientists in Creative Biolabs summarize existing knowledge and technologies to propose enhanced glycoprotein synthesis approaches such as native chemical ligation, bacterial oligosaccharyltransferase, glycoprotein remodeling, and in vivo suppressor tRNA technology.
On the other hand, the complexity of the glycan structures, the multiple substitutions at glycosylation sites, and the structural diversity associated with the protein backbone posed a giant challenge for the glycoprotein analysis. Therefore, Creative Biolabs provides staining and affinity-based methods to carry out a reliable detection of glycoproteins. Glycoprotein gel-staining estimates whether a protein is glycosylated by chemically restructuring the sugar groups of glycoproteins to addressing the unreactive glycan sugar moieties, while the affinity-based glycoprotein detection facilitates the determination of the glycosylation type by saccharide-binding proteins, enzyme-based methods, and antibody-based methods, which label and isolate glycosylated proteins containing a specific sugar (such as O-GlcNAc or mannosamine) with high specificity and efficiency.
“Supported by our skillful and knowledgeable team, we can guarantee a comprehensive custom synthesis service from beginning to end. Our experts who are proficient at glycoprotein synthesis will keep track of project progress and give guidance in real-time,” introduced by the senior scientist at Creative Biolabs.
“Meanwhile, our detection methods can specifically detect glycosylated proteins with high accuracy and sensitivity. Even extremely small amounts of glycoproteins can be tested through our detection system. The minimized batch-to-batch variations can assure of stability and consistency.”
With years of experience accumulated in a number of glycoprotein detection projects, Creative Biolabs can apply high-quality products and services with competitive price advantages to meet specific project needs. More information can be found at https://www.creative-biolabs.com/glycoprotein.
Equipped with the latest world-leading technology platforms and professional scientific staff, Creative Biolabs is dedicated to providing high-quality glycoprotein production and corresponding analysis service. The experienced scientists have developed a variety of different production platforms (such as bacteria, mammalian cells, insect cells, yeast cells, and plant cells) for glycoprotein production purposes. Creative Biolabs has also successfully developed several effective strategies to provide a series of cell line glycoengineering services. Based on our versatile glycoprotein analysis platforms, Creative Biolabs provides a glycoprotein analysis portfolio including glycoprotein detection, glycoprotein structure analysis, and glycoprotein quantification. Glycoprotein structure analysis mainly focuses on N-/O-glycan profiling, N-/O-glycomic profiling, glycosylation site mapping, and glycan sequencing.
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States