Creative Biostructure, featured as a leader in the structural biology field, now provides a comprehensive list of custom membrane protein services from gene to structure with an emphasis on protein purification, crystallization, structure determination and analysis.
Although membrane proteins play an important role in all organisms, their purification has historically, and continues to be, a huge challenge for protein scientists. In 2008, 150 unique structures of membrane proteins were available, and by 2019 only 50 human membrane proteins had their structures elucidated. For the important roles they play in cell functions, membrane proteins are now considered to be perfect drug targets. Investigating membrane protein structure and function can provide valuable information for drug characterization and optimization, however, such proteins are inherently difficult to purify and characterize. Even when expressed at high levels, the purification can still be challenging.
Membrane protein expression systems include:
Cell based membrane protein expression
Cell free membrane protein expression
Protein detergent-free expression
Animal free recombinant protein expression
Plasma membrane protein isolation
Native protein purification
In addition, Creative Biostructure also provides customized membrane protein services according to its customers’ specific requirements which include: Protein domain prediction, Plasmid design and construction, Protein expression, Protein purification, Protein process development and manufacturing.
More information can be accessed here: https://www.creative-biostructure.com/custom-membrane-protein-services_25.htm.
About Creative Biostructure
Creative Biostructure is specialized in providing contract services to both academia and biotech/pharmaceutical industries in the field of structural biology. We offer insightful strategies and cost-effective services on structure determination of macromolecules using X-ray Crystallography, EM, NMR, etc.