Profacgen Provides One-stop Antibiotic-free Protein Production Service for the Science Community

Now, Profacgen offers a one-stop antibiotic-free expression system, including construct designing, cloning and protein expression.

New York, USA – August 31, 2020 – Backed by a team of experienced protein biologists, Profacgen provides a comprehensive portfolio of expression systems to offer its clients with highly efficient and high-quality recombinant protein production, process development and scale-up production for downstream applications. Now, Profacgen offers a one-stop antibiotic-free expression system, including construct designing, cloning and protein expression.

Expression vectors with inserted antibiotic resistance genes are mainstream recombinant expression systems, and antibiotics are used during fermentation to avoid the growth and control of plasmid-free cells. However, antibiotic residues in protein products often cause allergic reactions in vivo, and the widespread use of resistance genes has led to the emergence of an increasing number of resistant strains in the environment. In addition, antibiotics can contaminate biomass or production products, and these contaminations are intolerable from an industrial and medical point of view.

To ensure that there are no residual antibiotics in the final product when antibiotics are used, it is necessary to demonstrate the residual antibiotic levels and remove them, which is also expensive. Therefore, the use of antibiotic-free systems has become an inevitable trend in the biomanufacturing industry.

The use of antibiotic selection plasmids has significant drawbacks, particularly when preparing therapeutic proteins. Antibiotic-free methods are more acceptable to regulatory agencies (e.g., FDA, EMEA) because the product will be safer for patients, and significantly lower cost processes can be designed because of reduced end product analysis (removal of antibiotics from the product).

Now, Profacgen can provide a new and highly effective stabilization system which is based on two kinds of genes. With this system, stable and high protein production is achieved and no antibiotic added into the production process.

“With all those features like making a perfect stabilization without using antibiotics, making the recombinant protein production purer, no specific modification required for DNA or protein production process or culture medium, and reducing the protein background other than the target protein, our services are surely to help accelerate your research,” commented Crystal, the chief marketing staff at Profacgen. “Our service can also be tailored according to your specific needs.”

More detailed information about the Antibiotic-free Protein Production Service at Profacgen can be viewed here:

About Profacgen

Profacgen provides process development and cGMP manufacturing services for biological active ingredients. We have ready access to state-of-the-art biopharmaceutical product development and manufacturing facilities and our staff scientists have demonstrable expertise in all aspects of biopharmaceutical manufacturing, from facility design and operation to the ability to provide best advice relating to product development.

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Company Name: Profacgen
Contact Person: Ellen Burns
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Phone: 1-631-619-7922
Country: United States