New York, USA – November 18, 2020 – Affinity is an important indicator of antibody quality, and a key parameter of antibody drugs since it usually affects the function and efficacy of antibodies. The higher the affinity, the higher the binding strength between the antibody and the corresponding antigen. Generally speaking, antibodies or humanized antibodies produced by hybridoma cell technology already have a relatively high affinity, but this may not be sufficient to meet the needs of therapeutic antibodies.
“Affinity maturation is a key operation to increase the affinity for an antibody. Different from the in vivo natural way, the in vitro affinity maturation is usually obtained by mutation and selection.” As introduced by a senior scientist at Creative Biolabs.
With years of exploration and extension, Creative Biolabs now provides optimized antibody affinity maturation service to help increase the affinity to an ideal level. Gathered a team of experts in antibody affinity maturation, Creative Biolabs usually takes scFv as the antibody format in affinity maturation. What’s more, a monovalent display phagemid system is available to reduce the avidity effects during antigen-binding screening.
In addition, scientists from Creative Biolabs have accumulated extensive experience from previous programs and now are highly skillful to perform antibody affinity and kinetics measurement with the most advanced systems, such as Biacore, ProteOn, Octet systems, etc. These systems enable a direct detection and measurement of molecular interactions in a real-time monitoring manner without labeling.
The aforementioned antibody affinity maturation and affinity measurement services can be provided in standard processes or in customized programs following the clients’ specific needs. All the data analysis will be performed and documented for reference. The scientist team will satisfy worldwide clients with the well-designed programs as well as the best after-sale services.
Creative Biolabs has been sweating over the field of antibody engineering for over a decade and has established a series of advanced platforms. Other antibody engineering services such as CAR construction, scFv/Fab construction and antibody stability improvement are also the focus of Creative Biolabs. More information can be reached on https://www.creative-biolabs.com.
About Creative Biolabs
With more than a decade of exploration and expansion, Creative Biolabs is recognized as one of the leading custom service providers, and has accumulated extensive experience in a wide range of antibody production and engineering fields. The one-stop service covers discovery services (phage display & antibody library services, sdAb services, antibody discovery services, etc), engineering services (antibody engineering, antibody labeling, immunologic analysis, etc) and bio-manufacturing (manufacturability assessment and optimization, membrane protein characterization, etc.).