Creative Biolabs, a Senior ADC Conjugation Chemistry Service Provider

After years of exploration and expansion, Creative Biolabs has developed into a successful service provider of antibody-drug conjugate (ADC) associated projects, which not only offers first-level custom services of ADC development, engineering, and analysis, but also supplies compliant products as support of global clients’ projects.

New York, USA – March 12, 2021 – “ADC drug is ushering in a new era,” said a scientist at Creative Biolabs, “which can be seen from our increasing orders.” Since the explosive increase of ADC drug approval in 2019, Creative Biolabs, an expert in ADC conjugation chemistry, has received a climbing number of inquiries.

Antibody-drug conjugates, as one of the fastest-growing drugs, represent a unique family of chemoimmunotherapy drugs that use specialized chemical linkers to couple monoclonal antibodies to cytotoxic small molecule drugs, of which the joint is to increase the therapeutic index by restricting the systemic delivery of drugs to cells expressing target antigens.

An ADC has three core components, which are an antibody that binds to tumor-associated antigens, a cytotoxic payload, and a linker bridging them. Creative Biolabs has one-stop ADC development solution that covers the entire pipeline of an ADC molecule production, which initiates from the design of an ADC, a delicate procedure that should take various factors into consideration. The clinical characteristics of an ADC depend on the characteristics of the three components, and each component may vary greatly between different ADCs, which may seriously affect its pharmacological and clinical characteristics. After the assembly of an ADC, Creative Biolabs will conduct an overall evaluation of its biochemical characteristics, in vitro efficacy, and in vivo pre-clinical pharmacological parameters.

* ADC in vitro analysis

Biochemical analysis: structural analysis, ADC stability analysis, drug antibody ratio (DAR) determination, conjugation sites analysis.
In vitro efficacy evaluation: ADC affinity evaluation, internalization assays, cytotoxicity assays, ADCC and CDC assays.
3D in vitro: ADC targeting profile, ADC tumor penetration, ADC solid tumor efficacy.

* ADC in vivo analysis

ADC pharmacokinetics characterization
ADC safety assessment
ADC in vivo efficacy evaluation
ADC immunogenicity analysis

Under the current COVID-19 epidemic, all the employees at Creative Biolabs keep to their post to make sure that all the projects run smoothly and on-time delivery. More details about the ADC solution can be accessed at https://www.creative-biolabs.com/adc.

Profile

Creative Biolabs is an expert in ADC conjugation chemistry, which has gone through over a decade of successful operation. A group of Master and Ph.D. level scientists specialized in biotech subjects with rich hands-on experience are the real strength of Creative Biolabs, who are quite skillful at developing antibody-drug conjugate products applicable for various research areas, such as lymphoma, leukemia, and lung cancer.

Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-830-6441
Country: United States
Website: https://www.creative-biolabs.com/adc