New York, USA – June 23, 2021 – Acroscell, the mature division of Creative Bioarray, is a leading provider that provides comprehensive range of preclinical services specialized in cardiovascular & neural system physiological/pathophysiological mechanisms and many other disease researches. Based on cutting-edge electrophysiological screening platform, Acroscell can reveal specific abnormalities in many genetic models of human cardiovascular & brain disease. Recently, Creative Bioarray develops drugs based on neuropharmacology in order to treat many different neurological disease.
There are two types of receptors for neurotransmitters on postsynaptic neurons. The first type of receptor is the ligand-gated ion channel or LGIC, which allows ions to flow directly into the cell. The second type is called G protein-coupled receptor or GPCR, which causes a cascade of intracellular interactions after binding. Many drugs developed today are related to disrupting this binding process.
The GABAa receptor is a ligand-gated ion channel (also called an ionotropic receptor) that responds to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which mediates rapid synapses in the central nervous system inhibition. GABA is the main inhibitory neurotransmitter in the central nervous system of mammals, the activation of GABA receptors often reduces the excitability of neurons.
Potassium channels usually have three states: static, activated and inactive. The channel is usually closed in a static state, opened after the stimulus is activated, and then turned into a non-conductive state. There are two mechanisms for K+ channel inactivation: N-type and C-type. Action potentials have different functions in neuron cell bodies and axons; in addition, various types of neurons have their own action potential patterns.
In addition, Voltage-gated sodium (Nav) channels are complete membrane proteins that can change conformation in response to the depolarization of membrane potential, open transmembrane pores, and conduct sodium ions inward to initiate and propagate action potentials. Sodium channels are essential for nerve conduction. Voltage-gated Na+ channel (VGSC) is the basic ion channel for neuronal excitability, which is essential for the generation and propagation of resting potentials and neuronal action potentials. Researchers have detected at least nine different sodium channel subtypes in the nervous system.
Over the past many years, neuropharmacology has contributed to many important advances in neuroscience. The effects of drugs that affect the nervous system are much more complicated than those that act on other organ systems. To understand how drugs act on the nervous system, it is essential to combine information about drug molecules and cellular actions with knowledge of how these actions affect brain circuits. The structure and function of brain circuits are constantly changing in response to pharmacology and non-drug inputs from the environment.
The methods supported by Acroscell mainly include:
Electrophysiology (Electrophysiology testing is an assessment of the function of nerves, not anatomy.)
Protein expression and purification
Structure determination and refinement
“Creative Bioarray will be the ideal and reliable innovation partner in your research work.” said Hannah Cole, the marketing director of Creative Bioarray, she also said, “We have a comprehensive cell bank with a variety of professional and unique stable cell lines expressing ion channels, which can be immediately applied to various in vitro studies and in vivo pharmacological studies.”
As a mature division of Creative Bioarray, Acroscell definitely will be the ideal and reliable innovation partner in research endeavors. With the support of professional scientists and years of experience, We are capable to provide a knowledgeable, collaborative and flexible service to our clients so as to accelerated drug development and improved research quality for worldwide projects.