New York, USA – July 30, 2021 – Microbialtec, a high-tech service company that specializes in microbiological research related issues, is dedicated to assisting researchers in exploring the hidden mysteries between microbes and health, production and the environment to make better use of microbial resources. With the experienced technical team in molecular biology, Microbialtec platform announced to provide microbial drug discovery services to support the research in drug discovery.
Microbialtec researchers are now extracting bacterial DNA from soil and marine habitats, cloning large fragments into, for example, bacterial artificial chromosomes, expressing and screening libraries of new compounds in host bacteria. This metagenomic effort has allowed people to access a huge library of untapped genetic and metabolic diversity. In addition, one of the latest methods to discover drugs from microorganisms is co-cultivation. In the co-cultivation strategy, Microbialtec can cultivate two or more organisms from different species. In this way, their physiological functions can be changed to produce mysterious compounds that cannot be produced in conventional culture media.
The microbial drug discovery services offered by Microbialtec include microbial metabolite profiling, chemotaxonomy-based drug discovery and bacterial genomes mining. For new compounds, more analogs can be generated through combinatorial chemistry or traditional chemistry. Alternatively, an automated UV guided search can be used to complete a comprehensive screening of new but similar compounds. A holistic combination method using comprehensive analysis and informatics techniques has recently been proposed as an intelligent screening strategy.
The starting point of target-based genome mining applications is to select specific chemical categories of natural products, and then mine genomic DNA sequences to obtain genes encoding products that specify the biosynthesis of corresponding molecular scaffolds. Once a candidate target is detected, different techniques (such as NMR, GC-MS, LC-MS) can be used to identify its designated secondary metabolites and increase its production to a level that allows purification and biological testing. The expression of candidate targets can be activated or enhanced in the host organism through genetic manipulation (such as the CRISPR/Cas9 system) and/or by optimizing growth conditions. Alternatively, it can be cloned and expressed heterologously in a well-characterized or engineered host.
“Combining rich project experience, strict data quality control and professional analysis process, we will ensure that the service is carried out accurately and quickly.” said Marcia Brady, the marketing director of Microbialtec, she also claimed, “We are committed to providing you with a one-stop microbiological solution, covering all stages from microbial sample collection to detection and analysis.”
About Microbialtec Platform
As a division of Creative Biogene, Microbialtec platform has an experienced technical team involving molecular biology, medicine, bioinformatics, statistical ecology. With 10 years of front-line scientific research experience, Creative Biogene supports customers with an overall microbiological research program, and is capable to satisfy the customized needs at affordable prices.