New York, USA – August 31, 2021 – Phosphoramidite solid-phase synthesis has become the gold standard method for DNA synthesis and has been used in the industry for nearly 35 years. Its simplicity and high efficiency have allowed the synthesis of a large number of oligonucleotide sequences, up to 200 base pairs in length.
BOC RNA has been a leading manufacturer of phosphoramidites and oligonucleotides for a long time and has a wealth of expertise and experience in these fields. It can provide a variety of types of high-quality phosphoramidites for the production of oligonucleotides for clinical applications. The range of products and services offered by this company is very suitable for customers who have strict requirements or need to control the manufacturing process.
The automated chemical synthesis of oligonucleotides is essential for the production of primers for polymerase chain reaction (PCR), oligonucleotide-based drugs, and many other medical and biotechnological applications. The highly optimized automated chemical oligonucleotide synthesis relies on phosphoramidite as the phosphate precursor.
The nucleoside phosphoramidite was first described in 1981. Phosphoramidites are modified nucleosides and are standard chemicals used in modern times. These molecules allow for the addition of new base sequences to the DNA strand in an extremely simple and extremely effective cyclic reaction.
The standard phosphoramidite molecule contains phosphites instead of the typical phosphates in nucleotides and four specific protecting groups. These groups provide stable protection but can be easily removed if necessary. This allows DNA chemists to expose only the reaction centers needed to produce DNA-like molecules, thereby providing a means of tightly controlling synthetic chemistry.
Currently, phosphoramidite solid-phase synthesis is the only commercially viable chemical method that can provide the amount of oligonucleotide (DNA) required by the synthetic biology market. BOC RNA can provide many improved versions of phosphoramidites, each with different characteristics optimized for specific oligonucleotide synthesis processes.
BOC RNA has extensive expertise in protection chemistry, modification, manufacturing amplification, and innovative purification strategies. With more than 15 years of manufacturing experience, it can confidently provide high-quality phosphoramidites for DNA and RNA oligonucleotide synthesis. Its phosphoramidite products are specially designed for oligonucleotide manufacturers who require high-precision impurity distribution and strict control of the process.
The phosphoramidite produced by BOC RNA can meet any specified specifications, and customers can fully control the entire process. All phosphoramidite products are guaranteed for stability and batch retention and are produced in dedicated cleanroom equipment to eliminate potential contamination. Each order has undergone strict QC and HPLC purification. BOC RNA is committed to the production of diagnostic oligonucleotides and to play a greater role in oligonucleotide therapy. Through flexible, user-defined ordering methods, the complete process can be easily managed and customized to meet the needs of each individual.
About BOC RNA
BOC RNA is a sub-brand of BOC Sciences, focusing on the broad prospects of nucleic acid chemistry and RNA technology in disease treatment. It provides a full range of phosphoramidite-related products and custom synthesis services, including standard phosphoramidites, DNA phosphoramidites, RNA phosphoramidites, dye-labeled phosphoramidites, linker phosphoramidites, Spacer Phosphoramidites, etc.