New York, USA – August 31, 2021 – CD Bioparticles, a leading manufacturer and supplier of various drug delivery products and services, now introduces a series of PROTAC Linkers with various molecular weight and functional groups, such as azide, acid, amine, biotin, NHC, tosyl, and fluorine, to accelerate researchers’ PROTAC study.
Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands; an “anchor” to bind to an E3 ubiquitin ligase and a “warhead” to bind to a protein of interest, connected by a chemical linker. CD Bioparticles manufactures and supplies various drug delivery products, including polymeric nanoparticles for R&D and commercialization in a variety of application areas, and now is offering a series of PROTAC Linkers for customers, such as (S,R. S)-AHPC-PEG4-Azide,(S,R. S)-AHPC-PEG2-acid, 4-Fluoro-thalidomide, D-Biotin-PEG6-Thalidomide, Pomalidomide-PEG5-Azide, Thalidomide-O-PEG5-Tosyl, Thalidomide-O-PEG6-NHS ester, and VHL Ligand 1 (hydrochloride).
For the (S,R. S)-AHPC-PEG4-Azide, it is a click chemistry PROTAC linker that incorporates an E3 ligase ligand with a PEG4 arm to empower PROTAC research & discovery. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media. Azide enables click chemistry with ALkyne or DBCO, BCN molecule.
For D-Biotin-PEG6-Thalidomide, it is a cereblon affinity probe for PROTAC and targeted protein degradation research. It can be used in cereblon (CRBN) binding and displacement assays for protein degrader validation experiments, CRBN ligand discovery, competition analyses, or where enrichment of CRBN complexes is required. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media.
Other examples, such as 4-Fluoro-thalidomide, the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1; Pomalidomide-PEG5-Azide, a PROTAC linker that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. Azide enables click chemistry with Alkyne, DBCO or BCN molecules; and the Thalidomide-O-PEG4-Propargyl, a synthesized compound that incorporates the Thalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. Propargyl is reactive with azide molecule in the presence of Cu catalyst.
“The PROTAC linkers we’ve launched recently in the areas of PROTAC research and development will offer our customers valuable tools for new scientific discoveries. We’ll continue to expand portfolio and offer more techniques and solutions to collaborate with our clients.” said Dr. Robin J. Watts, the scientific officer of R&D department of CD Bioparticles. “The new PROTAC linkers will serve science communities by being as a basic, but critical scientific tool to our customers for research use to enable them quickly get reliable results.”
Please feel free to contact CD Bioparticles to learn more about PROTAC linkers in order to find the right one for your studies. For more detailed information, please visit CD Bioparticles at https://www.cd-bioparticles.net.
About CD Bioparticles
CD Bioparticles is an established drug delivery company which provides customized solutions for developing and producing new, biocompatible drug delivery systems. It specializes in a range of formulation and drug delivery technologies, from conventional liposomes, PEGylated liposomes for drug delivery to polymer microspheres and nanoparticles for enhanced drug delivery. It provides contract services of drug delivery formulation developments for basic research, formulation feasibility studies, process development and scale-up, formulation characterization, analytical and nonclinical services.