New York, USA – September 9, 2021 – IntegrateRNA, the branch of Creative Biogene, utilizes high-quality products and services to optimize solutions for RNA discovery, expression analysis, functional research, and mechanism analysis. With unique technologies and comprehensive services, IntegrateRNA enables researchers to better understand human diseases, explore potential treatments for high-impact diseases and promote the development of the RNA research field. Recently, IntegrateRNA provides cholesterol-oligonucleotide conjugation to optimize the stability, cellular uptake, pharmacokinetic features of the therapeutic oligonucleotide.
IntegrateRNA provides cholesterol/cholesterol-TEG conjugated oligonucleotides in which the cholesterol group is attached to the 5′-end, 3′-end or inside of the oligonucleotide. Based on years of experience in oligonucleotide synthesis and modification, IntegrateRNA can incorporate cholesterol groups into modified siRNA, ASO and antagomir to improve its stability and enhance cellular uptake. With high-efficiency cholesterol TEG conjugate, and various purification grades, including research-grade and cGMP grade, the services provided by IntegrateRNA follow strict quality assurance and quality control.
As a global supplier, IntegrateRNA also provides high-quality functional PEG and PEG derivatives, which are essential for PEGylated therapeutic oligonucleotides. Based on an advanced PEGylation platform, IntegrateRNA uses a chemical coupling method to produce customized PEGylated oligonucleotides. In addition, IntegrateRNA provides complete PEGylation method development services, including polyethylene glycol derivative screening, analysis and characterization, bio-conjugation method development and optimization, and PEGylated oligonucleotide production.
IntegrateRNA has provided oligonucleotide and peptide synthesis with a wide range of chemical modifications for many years. With comprehensive expertise in synthesis, modification and bioconjugation, IntegrateRNA can provide high-quality and high-yield peptide-oligonucleotide conjugates (POC) customized production. Based on a strict quality evaluation and quality control system, each POC is carefully monitored during the synthesis process, purified by HPLC, and QC tested by mass spectrometry or gel electrophoresis.
IntegrateRNA has highly skilled scientists dedicated to biological coupling and cross-linking technology, providing coupling services, combining oligonucleotides with proteins, including fluorescent proteins, carrier proteins and enzymes. The coupling services provided by RNA platform include oligonucleotide/protein modification, activation and coupling. The experienced technical team can help customers produce high-quality oligoprotein conjugates and flexibly adapt to customers’ special requirements.
“IntegrateRNA uses chemical coupling methods to connect functional ligands to oligonucleotides including siRNA, ASO, miRNA, to optimize the stability, cellular uptake and pharmacokinetic characteristics of therapeutic oligonucleotides.” said Marcia Brady, the marketing director of Creative Biogene, she also said, “Our one-stop solutions include oligonucleotide synthesis, modification and coupling. We provide customized oligonucleotide coupling services and implement a strict QC process. Furthermore, we can also provide customized oligonucleotide coupling services to satisfy different needs.”
IntegrateRNA, as the division of Creative Biogene that holds a leading position in providing complete solutions for RNA research, has years of experience in next-generation sequencing and develops microarray platforms that enable researchers to explore the world of RNA on an unprecedented scale, and mapping all RNAs involved in cell life programs, human diseases, and drug discovery.