Shirley – Jul 19th, 2017 – British Journal of Cancer released the study result about the differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance by scientists from University of Aberdeen.
This study first elucidates the breakdown of omega-3 and omega-6 fatty acid enzymes and colorectal cancer patients The correlation between survival rates. Enzyme molecules capable of breaking omega-3 fatty acids are often directly associated with an increased survival rate in patients with colorectal cancer if they are highly concentrated.
Characterizing the expression of omega fatty acid metabolising enzymes CYP4A11, CYP4F11, CYP4V2 and CYP4Z1 using monoclonal antibodies with fatty acid analysis. Immunohistochemistry was performed on a tissue microarray containing 650 primary colorectal cancers, 285 lymph node metastasis, and 50 normal colonic mucosa.
‘The survival of patients with colorectal cancer often varies, and the response of patients to different reactions is often different, we do not know why some patients can produce an effective response to the therapy, but some not, that is, we carry out The aim of this study is that molecules or metabolites derived from omega-3 fatty acids can inhibit tumor proliferation.’ Said Professor Graeme Murray, one of the researchers for this study. ‘We speculate the metabolites of omega-3 fatty acids will increase as the level of omega-3 fatty acids is broken The corresponding increase, which will effectively inhibit the spread of the tumor.’
The lower the risk of tumor proliferation, the better the prognosis of patients; the other hand, if the omega-6 fatty acid metabolic enzyme and omega-3 fatty acid metabolic enzyme ratio (Ω-6 / Ω-3) will make the poor effect on the prognosis of patients. In the previous studies, it was not clear that the relationship between these two enzymes (metabolic enzymes of omega-3 and omega-6) was directly related to the survival rate of patients with colorectal cancer. This study elucidated this connection and figured out a potential pathway to help improve the survival rate of patients with colorectal cancer.
This study detail is available on British Journal of Cancer:
About Free Fatty Acid Analysis
Free Fatty Acid Analysis, with the coupling of MS methods to GC, much has been completed in the area of qualitative characterization of FAME mixtures. Owing to GC–MS provides spectrometric information on separated compounds, it provides a means of analyte selectivity; thus, detection with MS also reveals a potentially powerful tool for quantitative analysis of FAME, especially in the presence of a convoluted biochemical background. Despite the potential benefits of GC–MS methodologies for quantitative FAME analysis, the more familiar FID is still favored in some laboratories, particularly among lipid specialists.
Currently, a reliable and reproducible fatty acid analysis method using highly sensitive LC-MS/MS platform for the identification and quantification of free fatty acids (Fames) in different sample types has been established by the scientists at Creative Proteomics.
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