Recently, Creative Biolabs, a professional contract research organization in the frontier of CAR-T therapy, released a brand new oncolytic adenovirus in order to enhance anti-tumour responses via a dual mechanism of action (MOA).
As a non-enveloped, linear and double-stranded DNA virus, adenovirus consists of 52 distinct serotypes, which enables to be categorized into six subgroups (A to F) in terms of their ability to agglutinate red blood cells and their oncogenic potential in rodents.
“Due to the capacity of selectively infecting and replicating in tumor cells, oncolytic adenovirus (Ad) has become a potential therapeutic treatment for cancer in these years. However, the oncolytic antitumor activity is average in eliminating tumors. For the sake of a more efficient performance, our team developed a variety of methods by designing single-vector armed Ads, such as the antibody-armed oncolytic virus, the cytokine-armed oncolytic virus, and so on.” said Dr. Monika Müller, Scientific Officer of Creative Biolabs.
“As for antibody-armed oncolytic virus, tumor-targeting mAbs and immunomodulatory mAbs are two general antibody categories applied to arm oncolytic virus. Our scientists can provide first class oncolytic visrueseither expressing tumor-targeting mAbs or immunomodulatory mAb to contribute greatly to your project. In addition, various cytokines are able to be used to arm oncolytic adenovirus, such as interleukin-12 (IL-12), interleukin 24 (IL-24), suppressor of cytokine signaling 1 (SOCS1) and so on.”
With an all-sided OncoVirapy™ platform, Creative Biolabs can offer a full range of customized, standardized and high-quality cytokine-expressing oncolytic Ads to promote your project development. We also provide many other types of oncolytic virus, including oncolytic virus expressing chemokine, oncolytic virus expressing immune checkpoint inhibitor, or any other customized oncolytic virus to meet your demand.
About Creative Biolabs
As a global company, Creative Biolabs have more than 200 talented and well-trained scientists located in different continents working closely with partners from the entire world to develop and produce medicines of tomorrow. Specifically, we are the established leading expert in TCR and CAR T&NK cell immune therapy development, as we offer the one-stop custom services that cover the entire new drug development pipeline. Additionally, we also offer an exclusive line of ready-to-use TCR and CAR T&NK cell construction products, such as virus packaging, purification, expansion and titer determination kits. Furthermore, we have built up a unique unparalleled CAR construction and production platform for all four CAR generations.
Company Name: Creative Biolabs
Contact Person: Bella Smith
Address:45-1 Ramsey Road
State: New York
Country: United States