Creative Biolabs, a world-leading biology company equipped with extensive experience now launched a cutting-edge CAR-T library technology to makes the great contribution to the selection of desired scFv generation.
In the view of several shortcomings of the classic strategy for a CAR vector construction, such as affecting the expression of scFv fragments or the recognition of tumor antigens, talented scientists from Creative Biolabs are working a way out by CAR-T library technology.
“Our CAR-T library technology is a development of T cell display, which is a novel antibody selection strategy based on T cell activation. Chimeric antigen receptor genes with a large pool of antibody fragments are constructed into vectors thus forming the CAR-T libraries. After transfection, T lymphocytes display CARs on their surface”, said a scientist in Creative Biolabs.
“This technology could ideally link the tumor specific antigen-antibody interaction with the effective activation of T cells. We offer multiple antibody formats in our CAR-T libraries, including scFv, Fab, VHH, scFab, etc. The diversity of our CAR-T libraries is typically around 108, which is sufficient to generate highly affinitive binders from 10 pmol to nmol. Meanwhile, the selection is a positive selection system based on T cell activation, ensuring that isolated antibody fragments are functional within a CAR context.”
Over years in the field of immunotherapy, Creative Biolabs has served numerous customers all over the world. These robust libraries can be directly applied in functional CAR-T cells selection process to speed up our clients’ projects for academic and clinical purposes.
About Creative Biolabs
As a global company, Creative Biolabs have more than 200 talented and well-trained scientists located in different continents working closely with partners from the entire world to develop and produce medicines of tomorrow. Specifically, we are the established leading expert in TCR and CAR T&NK cell immune therapy development, as we offer the one-stop custom services that cover the entire new drug development pipeline. Additionally, we also offer an exclusive line of ready-to-use TCR and CAR T&NK cell construction products, such as virus packaging, purification, expansion and titer determination kits. Furthermore, we have built up a unique unparalleled CAR construction and production platform for all four CAR generations.
Company Name: Creative Biolabs
Contact Person: Bella Smith
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States