Changes in Energy Metabolism in Piglets During Their Suckling Period, A Research by Dr. Yulong Yin

Abstract:

Dr.Yulong Yin, a renowned Chinese scientist in the field of animal nutrition and feed science, has done an outstanding research on energy metabolism of piglets during their suckling period. Dr. Yulong Yin and his team have tested the hypothesis that the energy metabolism of piglets will change during their suckling period. For this, his team has started an experiment with 24 piglets from 8 different litters. Out of 8 litters, 3 piglets were collected from each litter making of 24 piglets for this experiment. One piglet was randomly selected from each litter and euthanized at 7, 14 or 21 days of age respectively. After that, they have extracted the crypt cells from mid-jejunum and done protein synthesis using isobaric tags for relative and absolute quantitation (iTRAQ). During this experiment, the production of proteins related to glycolysis was decreased from days 7 to 14, also the synthesis of proteins involved in fatty acids, amino acids and citrate cycle metabolism was low when compared with the samples collected from days 14 and 21 with day 7. Therefore, from the results obtained by Dr. Yulong Yin and his team from this experiment indicated that the energy metabolism in the intestinal crypt epithelial cells of a piglet changes during their suckling period. From this study, it will be helpful in regulating the intestinal development of piglets.  

Results:

According to gene ontology (GO) enrichment analysis of biological process, the synthesized proteins which were obtained from epithelial cells of mid-jejunum are mainly within the categories of cellular process, metabolic process, biological regulation, pigmentation, localization, multicellular organismal process, establishment of localization, response to stimulus, and developmental process. See below for the detailed pie chart of the above said.

Discussion:

Piglets during 3-4 weeks of their age are usually weaned. During their suckling period, their gastrointestinal track grows rapidly within the first four weeks of their age. For example, the weight of small intestine of a piglet increases six-fold within the first four weeks of its age.  The major change occurs in the intestinal mucosa itself and also, the size, shape, height and density of the small intestine will also be altered during the first three weeks of piglet’s age. Similar changes like alteration in intestinal size, shape and weight also observed in mice and rats.

Dr. Yulong Yin and his team have found that the synthesis of proteins related to rapid increase in cell numbers in the crypt which supports their previous study demonstrating the relationship between piglet lactation and rapid increase in cell numbers in the crypt.  

Conclusion:

Finally, from the above experiment, Dr. Yulong yin and his team has concluded that, there will be changes in metabolic activity in the crypt epithelial cells of piglets during their suckling period. Also, the glucose metabolism will increase and metabolism of fatty acids and amino acids will decrease during this period. This study will help in regulating the intestinal development in piglets during their suckling period.

About the Author:

Dr. Yulong Yin, Academician at the Chinese Academy of Engineering, is a renowned Chinese scientist in the field of animal nutrition and feed science. He and his team published a total of 318 SCI articles which have been cited 8,165 times (including 5,748 cites by the world-famous magazine Nature, and PNAS (American Academy of Sciences), among others). With an H-index of as high as 48, he was listed among Thomson Reuters Citation Laureates in both 2014 and 2015 and was honored as a Chinese Citation Laureate (the only winner in the Chinese agricultural sector). His other publications include another 389 articles in Chinese journals with 3,933 citations (among which, 3,625 citations by others) and six Chinese or English monographs. In addition, he obtained 38 patents for invention.

Dr. Yin and his team made major breakthroughs in addressing pressing issues of nutrition, pig feed formulations, and pollutions caused by pig production. The team focused on improving nutrient utilization rate in pig feed. Through technical innovations in fistula and portal vein cannulation, they put in place a regulatory system for pig intestine energy, protein, amino acids and trace elements, and developed functional pig nutrition regulators and environmentally friendly feed products.

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