Cardiomyocyte Hypertrophy and Systolic Heart Failure: A Critical Correlation Established by Dr. Richard Tracy

In spite of enough evidence that right ventricular (RV) function is a critical determinant of the clinical response to a domain of cardiovascular diseases, including systolic heart failure, there has been only a limited evaluation of the peculiar and distinctive physiologic properties of the RV under normal circumstances and in reciprocation to pathologic insults.

This shortfall of knowledge is continually acknowledged by Researchers at Pathologist for Orleans Parish Forensic Center, LA, USA. The observational review undertaken by researchers in correspondence with Richard E Tracy, Pathologist for Orleans Parish Forensic Center, LA, USA illustrated features and accentuated the fact that rational therapy in RV failure requires hand over to its unique physiology and preconditioned to chamber specific. That is clinically proven/evidence established therapies for LV dysfunction does not inevitably apply to the RV.

The updated version of Richard’s review submits to recent advances in the understanding of inflammatory, metabolic, and gender-specific influences on the right and left ventricle and any proposed contractile weakening.

To undertake the study, the Orleans Parish Coroner’s Office has been supplied a series of 104 specimens during accessible days November 2007 and September 2012. All cases with cardiomegaly (whole heart weight>449 g in men and >399 g in women), were received, except those with RV, valvular, or ischemic disorders. Non-cardiovascular cases without cardiomegaly has been singled-out to have

To interrogate this pattern more comprehensively, the author proceeded doing the curve fitting on each of the 104 cases. As an outcome, the refusal of fitted log normal curves by the Shapiro- Wilk test occurred unduly often in both RV and LV but did not favor the most hypertrophied specimens.

This author’s frame of reference is embodied by the pool of most hypertrophied specimens, which demonstrates the lack of truncation in the upper tail. The RV reaches this hypothesized limit at average myocyte sizes fairly smaller than those concurrently viewed in the LV. The cumulative findings indicate that the attained myocyte size does not, fundamentally, enforce the limit upon the largest cells. Rather, what appears is that a definite number of myocytes containing a ventricle must each grow larger in unison with the LV spherical model regardless of contractile strength of individual myocytes.

In conclusion, author mentions that outcome would need that myocytes of all sizes must be subdued similarly, so that the frequency distribution holds on to its shape throughout the process. Limits dictated only upon the largest cells should curtail the upper tail of the bell shaped curve, a decree not discerned in the LV data.

Pathologist Richard E Tracy, corresponding author of the study also says: Systolic heart failure, due to dysfunctional systolic function, results from low or high output status. It can involve the right or left ventricle (LV), or both. The size of the left ventricle (LV) is disposed to increase progressively in answer to volume overload & pressure overload. The study author further displayed the high sign associated with volume & pressure overloads that initially act to broaden the LV myocyte transverse dimension (MyL=breadth of LV myocytes) and that volume overload stretches myocyte length throughout to spectrum of hypertrophy.

These types of hypertrophy encounter ceilings prescribed upon cellular lengths and breadths processes that are not clearly understood. Considering hypertrophy of cell breadth, the author advocated that the largest myocytes desist to grow, or may fall away by apoptosis or necrosis, or even subject to longitudinal splitting, after spanning up to a fence to what is biologically possible.

Additionally, mentioning that, Cardiac diseases are among the natural conditions often encountered by forensic pathologists; and this condition puts them on the front line to attend these matters. The author lastly speaks briefly on the importance of the readily available and most accurate and reproducible evaluation of cardiac function, as well as, the research system close linkage between basic and clinic to prevent and cure heart failure in the elderly societies.

Since, none of the conventional imaging techniques can provide such all-inclusive service. The author stresses upon that the chosen tool must have the adept to reveal the underlying etiology and any contributory determinant of heart failure, which should subsequently be suitable for serial evaluations that can supervise modes of intervention, optimize drug therapy, and track treatment response. The revelations of the study show great potential for establishing a gold standard investigation of kind for heart failure.

Richard E Tracy is a former Professor at Emeritus, LSUHSC/NO serving since 2005. His commendable work in the field of scientific research has been published across countries. He is presently the bestselling author, keynote speaker, social media influencer, and chief clinical researcher. That’s not giving you a lot of his details, is it? So know more about him here.

He has received numerous accolades; including Bausch and Lomb Medal for student research -1961 being the earliest and Joseph A. Capps Award – 1965, the most notable. He is an extensive educated workforce who knows how to exploit new technology for the benefit of the living world.

Richard E Tracy tells you when he works in an awesome way, the memberships bothers to subscribe to him. He is currently a fellow member of the highly prestigious associations including:

Society memberships

• American Medical Association

• American Heart Association  

• American Society of Investigative pathology

• Louisiana State Medical Society

• International Academy of Pathology

• Council on Arteriosclerosis

The scholarly Richard is also recognized to have great educated tastes, adding to his expansive erudite:

• M.D. –  University of Chicago – 1961

• Ph.D. – University of Chicago – 1961

• Medical School, Senior year – 1960-1961

• USPHS Fellowship Trainee in Pathology – 1958-1960

• Medical School, Freshman-Junior years – 1955-1958

• University of Chicago, Chicago, Illinois – 1955                                           

Before devoting his work fulltime to Emeritus, LSUHSC/NO, Richard served as:

• Professor of Pathology, Louisiana State University School of Medicine – 1977 -2005

• Visiting Pathologist, LSU Division, Charity Hospital, New Orleans – 1969 -2005

• Pathologist to the Coroner of Orleans Parish – 1976-1985

• Rotating Internship, Presbyterian Hospital, Denver – 1961-1962

• Research Associate, Department of Pathology, University of Chicago — 1962-1964

• Instructor in Pathology, University of Chicago — 1962-1965

• Assistant Professor of Pathology, University of Oregon Medical School – 1965-1967

• Assistant Professor of Pathology, Louisiana State University School of Medicine 1967-1971

• Associate Professor of Pathology, Louisiana State University – 1971-1977

• Professor of Pathology, Louisiana State University School of Medicine – 1977 –

• Visiting Pathologist, LSU Division, Charity Hospital, New Orleans — 1969 -2005

• Pathologist to the Coroner of Orleans Parish — 1976-1985

• Member of Veterans Administration Merit Review Board – 1983 – 1985

• Pathologist to the Coroner of Washington Parish – 1986 – 1998

• Diplomate, American Board of Pathology: Forensic Pathology – 1997

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