New York, USA – As one of the most trustworthy research partners, Creative Biolabs has been dedicated to enhancing a wide range of Non-human Primates models for different immune diseases, including allergic asthma, allergic rhinitis and rheumatoid arthritis (RA).
By virtue of the most similar biological features to that of humans, especially the closet genetic information, non-human primates (NHPs) are widely used in the research of various diseases. NHP disease models that include allergic asthma models, allergic rhinitis models and rheumatoid arthritis models from Creative Biolabs can produce more accurate and convincing data for pathogenesis characterization as well as preclinical research on immune disease.
1. Allergic asthma models
Creative Biolabs provides well-tailored allergic asthma models according to customers’ needs. A comprehensive portfolio of evaluations can also be conducted, including but not limited to total cell numbers and differential cell counts in bronchoalveolar lavage fluid (BALF), total and OVA-specific IgE levels in serum, IL-4, IL-5 and IL-13 levels in BALF and lung tissue (ELISA), IL-4, IL-5 and IL-13 transcription levels in lung tissue (qRT-PCR), lung function test, histopathology analysis of infiltration.
2. Allergic rhinitis models
Creative Biolabs can provide a full list of different allergic rhinitis models according to different requests. For instance, standard NHP models with all kinds of allergens, such as bovine serum albumin (BSA), ovalbumin (OVA), ascaris extract, SEA, or with various adjuvants, such as complete Freund’s adjuvant (CFA), aluminum hydroxide gel (alum), lipopolysaccharide (LPS), bordetella pertussis vaccine, can be prepared within a fast turnaround time.
Sensitized animals can also be created at Creative Biolabs by either inhalation using intranasal, intratracheal or aerosol routes. At the same time, a full set of endpoint measurements are provided including eosinophil infiltration in nasal mucosa, serum level of allergen-specific IgE measured by solid-phase enzyme-linked immunosorbent assay (ELISA), Th2 and Th1 cytokines levels measured by ELISA from the centrifuged serum and nasal lavage.
Supported by a Ph.D. level scientist team, Creative Biolabs has managed to overcome the conventional limitations of NHP RA model and successfully induce RA in cynomolgus monkeys using type II collagen. NHP RA models developed by Creative Biolabs have proved good utility in rheumatology studies, inflammation related anemia and pain studies. A full set of evaluation and validation measures are available, including body weight, primary endpoints for evaluating arthritis, disease incidence, arthritic incidence of proximal interphalangeal joints, measurement of joint swelling, arthritic score.
Apart from immune diseases, Creative Biolabs is also an expert in Cardiovascular and Metabolic Disorders, Liver Disease, Neurological Disease, Renal Disease, and Urogenital Disease. More information can be reached at https://www.creative-biolabs.com/drug-discovery/therapeutics.
About Creative Biolabs
Creative Biolabs is one of the few companies who can offer integrated drug discovery services for clients all over the world. Talented and well-trained scientists are working closely with each other to realize the goal of our customers. To discover and develop the qualified medicines of tomorrow, the scientists, who are concentrating on every important aspect of the industry, especially for the drug discovery pipeline, are able to undertake the entire discovery pipeline but also pleased to offer specific service based on clients’ requirements. Creative Biolabs offers comprehensive services ranging from target identification and validation, hit identification, hit to lead, lead optimization to the investigational new drug (IND).
Company Name: Creative Biolabs
Contact Person: Candy Swift
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Country: United States